P53 Activator 17

P53 Activator 17 is a p53-Y220C activator. p53 Activator 17 exhibits selective cytotoxicity and pro-apoptotic activity in p53-Y220C mutant cancer cell lines, with minimal effects in wild-type or p53-null cells. p53 Activator 17 induces a mutant-to-wild-type conformational shift in cellular p53-Y220C, accompanied by transcriptional activation of canonical p53 target genes, including BBC3 (PUMA) and MDM2. p53 Activator 17 can be used for the study of hepatocellular carcinoma and breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; MDM-2/p53

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

BrC1=CC=C2C(C(N3C=CC=C3)=NN2CCN(C)C)=C1

Molecular Formula

C15H17BrN4

Molecular Weight

333.23

References & Citations

[1]Khadiullina R, et al. Cellular activity upregulation of the thermolabile p53 cancer mutant Y220C by small molecule indazole derivatives. Cell Death Discov. 2025 Nov 7;11 (1) :508.