FLT3-IN-37
FLT3-IN-37 (Compound 6z) is a potent inhibitor of FLT3-ITD, with IC50 values of 1.5 and 3.4 nM for FLT3-ITD and TEL-VEGFR2, respectively. FLT3-IN-37 exhibits high selectivity for wild-type FLT3 (WT) and c-Kit. FLT3-IN-37 inhibits FLT3 phosphorylation and downregulates the expression of p-Akt, p-STAT5, and p-ERK. FLT3-IN-37 exerts anti-leukemia effects by blocking the cell cycle and inducing apoptosis (apoptosis) . FLT3-IN-37 can be used for research on acute myeloid leukemia (AML) [1].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; ERK; FLT3; STAT; VEGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC1=CN(N=C(C1=O)C(NC2=CC=C(C(F)=C2)OC3=CC=NC(NC(N4CC(C4)O)=O)=C3)=O)C5=CC(Cl)=C(C=C5)F
Molecular Formula
C27H21ClF2N6O5
Molecular Weight
582.94
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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