ChE/GSK-3β-IN-1
ChE/GSK-3β-IN-1 (compound 18o) is a potent dual ChE/GSK-3β inhibitor. ChE/GSK-3β-IN-1 exhibits dual inhibition of AChE (IC50 = 1.7 μM), butyrylcholinesterase (BChE) (IC50 = 5.3 μM), and GSK-3β (IC50 = 5.7 μM) . ChE/GSK-3β-IN-1 inhibits Aβ1-42 self-aggregation. ChE/GSK-3β-IN-1 can be used for Alzheimer’s disease (AD) research[1].
Product Specifications
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; GSK-3
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
O=C1CC2=C(C3=CC=CC=C3N1)NC4=C2C=C(C=C4)C(NCCCNC5CCCCC5)=O
Molecular Formula
C26H30N4O2
Molecular Weight
430.54
References & Citations
[1]Raghuvanshi R, et al. Design, synthesis, and biological evaluation of kenpaullone derivatives as potential dual inhibitors of cholinesterases and glycogen synthase kinase-3β. Bioorg Chem. 2025 Dec;167:109232.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; GSK-3β
Curated Selection
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