ACI-19278

ACI-19278 is a TDP-43 PET tracer with an average Kd of 25 nM. ACI-19278 only binds to pathological TDP-43 aggregates and does not cross-react with Aβ, Tau, etc. [18F]ACI-19278 successfully visualized the TDP-43 pathology in the human brain through positron emission computed tomography. ACI-19278 can be used for in vivo diagnosis of TDP-43 protein lesions[1].

Product Specifications

CAS Number

[3033951-64-0]

UNSPSC

12352005

Target

HnRNP

Related Pathways

Epigenetics

Field of Research

Neurological Disease

Smiles

FC1=C(C2=NC(CCN(C3=CN=CC=C3)C4=O)=C4S2)C=CC(N5CC[C@@H](F)C5)=N1

Molecular Formula

C20H17F2N5OS

Molecular Weight

413.44

References & Citations

[1]Vokali E, et al. Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology. Nat Commun. 2025 Oct 24;16 (1) :9358.