ACI-19278
ACI-19278 is a TDP-43 PET tracer with an average Kd of 25 nM. ACI-19278 only binds to pathological TDP-43 aggregates and does not cross-react with Aβ, Tau, etc. [18F]ACI-19278 successfully visualized the TDP-43 pathology in the human brain through positron emission computed tomography. ACI-19278 can be used for in vivo diagnosis of TDP-43 protein lesions[1].
Product Specifications
CAS Number
[3033951-64-0]
UNSPSC
12352005
Target
HnRNP
Related Pathways
Epigenetics
Field of Research
Neurological Disease
Smiles
FC1=C(C2=NC(CCN(C3=CN=CC=C3)C4=O)=C4S2)C=CC(N5CC[C@@H](F)C5)=N1
Molecular Formula
C20H17F2N5OS
Molecular Weight
413.44
References & Citations
[1]Vokali E, et al. Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology. Nat Commun. 2025 Oct 24;16 (1) :9358.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-179492/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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