AM-0883
AM-0883 is a TRPC6 (Transient receptor potential canonical 6) agonist (hTRPC6 EC50 = 46 nM) . AM-0083 can be used for the study of cardiac and renal diseases[1][2].
Product Specifications
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
O=C(N1CCC2(C(C=C(Cl)C=C3)=C3NC2)CC1)[C@@H]4OC5=CC=CC=C5OC4
Molecular Formula
C21H21ClN2O3
Molecular Weight
384.86
References & Citations
[1]Bai Y, et al. Structural basis for pharmacological modulation of the TRPC6 channel. Elife. 2020 Mar 9;9:e53311.|[2]Chubanov V, et al. Physiological functions and pharmacological targeting of transient receptor potential channels. Pharmacol Rev. 2025 Nov;77 (6) :100089.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPC6
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