(±) 8 (9) -EET
(±) 8 (9) -EET is one of the main metabolites produced by the metabolism of arachidonic acid (HY-109590) through the cytochrome P450 epoxide pathway. (±) 8 (9) -EET is an effective substrate for COX-1 and COX-2. (±) 8 (9) -EET activates PPARα in HEK293 cells and inhibits the activity of NF-κB induced by IL-1β in a PPARα-dependent and -independent manner. The (8S,9R) -isomer of (±) 8 (9) -EET ([ (8S,9R) -EET]) causes vasoconstriction, thereby reducing renal plasma flow and glomerular filtration rate[1][2][3][4][5].
Product Specifications
CAS Number
[184488-44-6]
UNSPSC
12352211
Target
COX; Drug Metabolite; NF-κB; PPAR
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
CCCCC/C=C\C/C=C\CC1OC1C/C=C\CCCC(O)=O
Molecular Formula
C20H32O3
Molecular Weight
320.47
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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