3-Oxochol-5-en-24-oic acid

3-Oxochol-5-en-24-oic acid is a rare bile acid produced by the intestinal microbiota. 3-Oxochol-5-en-24-oic acid is a potent antagonist of the human androgen receptor (hAR), with an IC50 of 119.4 nM. 3-Oxochol-5-en-24-oic acid has no significant agonistic or antagonistic effects on estrogen receptors (ER) or glucocorticoid receptors (GR) . 3-Oxochol-5-en-24-oic acid effectively inhibits the growth of prostate cancer cells. In animal models, it enhances the efficacy of anti-PD-1 therapy by regulating the differentiation of CD8+ T cells. 3-Oxochol-5-en-24-oic acid can be used for research on regulating host immunity and anti-tumor studies[1].

Product Specifications

CAS Number

[847232-54-6]

UNSPSC

12352211

Target

Androgen Receptor; Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Inflammation/Immunology

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC(CC4)=O)=CC3)C

Molecular Formula

C24H36O3

Molecular Weight

372.54

References & Citations

[1]Jin WB, et al. Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity. Cell. 2025 May 1;188 (9) :2336-2353.e38.