KP-2067

KP-2067 is a form of the CaSR agonist peptide. KP-2067 can result in dose-dependent activation of CaSR in HEK293T overexpressing hCaSR cell line, with an EC50 of 18.4 μM. KP-2067 significantly reduces plasma parathyroid hormone in rat model[1].

Product Specifications

CAS Number

[1262781-19-0]

UNSPSC

12352209

Target

CaSR

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Smiles

N=C(N)NCCC[C@H](C(N)=O)NC([C@@H](C)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](C)NC([C@@H](CS)NC(C)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C35H68N20O8S

Molecular Weight

929.11

References & Citations

[1]Alexander, S. T., et al., (2015) . Critical Cysteine Residues in Both the Calcium-Sensing Receptor and the Allosteric Activator AMG 416 Underlie the Mechanism of Action. Molecular pharmacology, 88 (5), 853-865.