TSI-13-57

TSI-13-57 is a pan-TLR inhibitor (IC50: 2.7 μM, 6.03 μM, 7.37 μM, 6.38 μM for TLR9, TLR7, TLR2, TLR4, respectively) . TSI-13-57 inhibits homodimerization of the TIR domains of MyD88. TSI-13-57 reduces systemic inflammatory responses in LPS-induced mice[1][2].

Product Specifications

CAS Number

[2257427-45-3]

UNSPSC

12352005

Target

MyD88; Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

OC1=CC=C(C2=CC(C3=CC=C(OCCN4CCCCC4)C=C3)=NN2C5=CC=C(C=C5)O)C=C1

Molecular Formula

C28H29N3O3

Molecular Weight

455.55

References & Citations

[1]Chen L, et al. Myeloid Differentiation Primary Response Protein 88 (MyD88) : The Central Hub of TLR/IL-1R Signaling. J Med Chem. 2020 Nov 25;63 (22) :13316-13329. |[2]Ippagunta SK, et al. Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins. Sci Signal. 2018 Aug 14;11 (543) :eaaq1077.