TSI-13-57
TSI-13-57 is a pan-TLR inhibitor (IC50: 2.7 μM, 6.03 μM, 7.37 μM, 6.38 μM for TLR9, TLR7, TLR2, TLR4, respectively) . TSI-13-57 inhibits homodimerization of the TIR domains of MyD88. TSI-13-57 reduces systemic inflammatory responses in LPS-induced mice[1][2].
Product Specifications
CAS Number
2257427-45-3
UNSPSC
12352005
Target
MyD88; Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
OC1=CC=C(C2=CC(C3=CC=C(OCCN4CCCCC4)C=C3)=NN2C5=CC=C(C=C5)O)C=C1
Molecular Formula
C28H29N3O3
Molecular Weight
455.55
References & Citations
[1]Chen L, et al. Myeloid Differentiation Primary Response Protein 88 (MyD88) : The Central Hub of TLR/IL-1R Signaling. J Med Chem. 2020 Nov 25;63 (22) :13316-13329. |[2]Ippagunta SK, et al. Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins. Sci Signal. 2018 Aug 14;11 (543) :eaaq1077.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR2; TLR4; TLR7; TLR9
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