CC-M-1
CC-M-1 is a potent and selective PI3K/mTOR inhibitor. CC-M-1 inhibits PI3Kα/β/γ/δ and mTOR with IC50 values of 0.68, 1.02, 1.03, 8.03, and 15 nM, respectively. CC-M-1 inhibits the proliferation of colorectal cancer cell lines, including HCT-116 (IC50 = 0.38 μM) and HT-29 (IC50 = 1.70 μM) . CC-M-1 can be used for colorectal cancer (CRC) research[1].
Product Specifications
CAS Number
3079943-00-0
UNSPSC
12352005
Target
MTOR; PI3K
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=C(C=C(C=N1)C2=NN3C(C4=CN(N=N4)CCCN5CCCC(C5)O)=CN=C3C=C2)NS(=O)(C6=C(C=C(C=C6)F)F)=O
Molecular Formula
C28H29F2N9O4S
Molecular Weight
625.65
References & Citations
[1]Wang Z, et al. Development of PI3K/mTOR-HSP90 ligand conjugates for improved colorectal cancer therapy. Eur J Med Chem. 2026 Jan 15;302 (Pt 2) :118286.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
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