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Nav1.7-IN-20

Nav1.7-IN-20 (Compound 3AG) is an orally active Nav1.7 channel inhibitor with an IC50 of 3.1 μM. Nav1.7-IN-20 demonstrates analgesic efficacy in a Complete Freund's adjuvant (CFA) inflammatory pain model. Nav1.7-IN-20 can be used for pain research[1].

Product Specifications

UNSPSC

12352005

Target

Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(N1CCCCC1)/C=C/C=C/C2=CC(OCC3=CC=CC=C3Br)=C(OCC4=C(Br)C=CC=C4)C=C2

Molecular Formula

C30H29Br2NO3

Molecular Weight

611.36

References & Citations

[1]Vikram VN, et al. Discovery of O-alkylated derivative of piperine as Nav1.7 channel inhibitor for the treatment of pain. Bioorg Med Chem Lett. 2026 Feb 1;131:130461.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Nav1.7

Frequently Asked Questions

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