SOS1-IN-25

SOS1-IN-25 is an SOS1 inhibitor. SOS1-IN-25 exhibits inhibitory activity against KRASG12C/SOS1 complex formation (IC50 = 11.11 nM) . SOS1-IN-25 leads to a dose-dependent decrease in pERK levels. SOS1-IN-25 can be used for the study of leukemia[1].

Product Specifications

CAS Number

[3092446-09-5]

UNSPSC

12352005

Target

Ras; SOS1

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Field of Research

Cancer

Smiles

CC1=NC(N[C@@H](C2=CC(C3=CC=CC=C3CNC)=CS2)C)=C4C(C(C)(C)C(N(C5CCOCC5)C4)=O)=N1

Molecular Formula

C29H37N5O2S

Molecular Weight

519.70

References & Citations

[1]Chen X, et al. Development and biological evaluation of novel SOS1 inhibitors featuring 5,8-dihydropyrido[4,3-d]pyrimidin-7 (6H) -one scaffold. Bioorg Med Chem Lett. 2025 Dec 1;128:130344.