AR ligand-48

AR ligand-48 is an AR (Androgen Receptor) inhibitor and a ligand for the target protein for PROTAC (AR) . AR ligand-48 can be used to synthesize PROTAC AR Degrader-12 (HY-179433) [1].

Product Specifications

CAS Number

[1318208-88-6]

UNSPSC

12352005

Target

Androgen Receptor; Ligands for Target Protein for PROTAC

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

COC(C1=CC(OCC(C)C)=C(C=C1)NC(C2=CC(OCC(C)C)=C(C=C2)[N+]([O-])=O)=O)=O

Molecular Formula

C23H28N2O7

Molecular Weight

444.48

References & Citations

[1]Wu Y, et al. Kill Two Birds with One Stone: An Efficient and Potent AR CBS-Targeted Degrader Reverses Breast Cancer Resistance via Concurrent AR Degradation and ERα Transcriptional Suppression. J Med Chem. 2025 Nov 27;68 (22) :24136-24167.