SEH/FLAP-IN-2
SEH/FLAP-IN-2 is a selective sEH (IC50 = 12.6 nM) /FLAP dual inhibitor. sEH/FLAP-IN-2 highlights the reduction of 5-LOX/FLAP- and sEH-derived LMs, resulting in a favourable redistribution of LMs. sEH/FLAP-IN-2 can be used for the study of peritonitis[1].
Product Specifications
UNSPSC
12352005
Target
Epoxide Hydrolase; FLAP
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(NCC1=CC=C(N)C=C1)C2=CC=C(NC(NCC34CC5CC(C4)CC(C5)C3)=O)C=C2N
Molecular Formula
C26H33N5O2
Molecular Weight
447.57
References & Citations
[1]Ciaglia T, et al. An adamantylureido-benzylamide aniline as FLAP/sEH dual inhibitor: Rational design, in vitro and in vivo lipidomic profiling. Eur J Med Chem. 2026 Jan 15;302 (Pt 2) :118338.|[2]Yang DM, et al. Discovery of novel indoline derivatives as potent small molecule PD-L1 inhibitors. Bioorg Med Chem Lett. 2026 Feb 1;131:130458.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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