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EA-C15

EA-C15 is a potent and selective TEAD inhibitor with an IC50 of 0.34 μM. EA-C15 covalently binds to the TEAD palmitoylation site, blocks palmitoylation and transcriptional activity, and inhibits YAP-dependent cancer cell proliferation and YAP-TEAD target gene (CTGF and CYR61) transcription. EA-C15 can be used for cancer research[1].

Product Specifications

UNSPSC

12352005

Target

YAP

Related Pathways

Stem Cell/Wnt

Field of Research

Cancer

Smiles

C=CC(NC1=CC=C(C(C2CCCCC2)=O)C=C1C3=CC=NN3C)=O

Molecular Formula

C20H23N3O2

Molecular Weight

337.42

References & Citations

[1]Chen W, et al. Discovery of repurposed ethacrynic acid and its derivatives as novel TEAD inhibitors. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118299.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TEAD

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