EA-C15
EA-C15 is a potent and selective TEAD inhibitor with an IC50 of 0.34 μM. EA-C15 covalently binds to the TEAD palmitoylation site, blocks palmitoylation and transcriptional activity, and inhibits YAP-dependent cancer cell proliferation and YAP-TEAD target gene (CTGF and CYR61) transcription. EA-C15 can be used for cancer research[1].
Product Specifications
UNSPSC
12352005
Target
YAP
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Smiles
C=CC(NC1=CC=C(C(C2CCCCC2)=O)C=C1C3=CC=NN3C)=O
Molecular Formula
C20H23N3O2
Molecular Weight
337.42
References & Citations
[1]Chen W, et al. Discovery of repurposed ethacrynic acid and its derivatives as novel TEAD inhibitors. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118299.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TEAD
Curated Selection
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