(S, R, S) -AHPC-Bromooctanoic acid

(S, R, S) -AHPC-Bromooctanoic acid is a conjugate of E3 ligase ligand and linker, consisting of (S, R, S) -AHPC (HY-125845) and the corresponding linker (HY-W007700) . (S, R, S) -AHPC-Bromooctanoic acid can serve as VHL (von Hippel-Lindau) ligand to recruit the VHL protein and serve as a key intermediate for the synthesis of complete PROTAC molecules[1].

Product Specifications

CAS Number

[2408342-03-8]

Product Name Alternative

VH032-NH-Bromooctanoic acid

UNSPSC

12352100

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

BrCCCCCCCC(N[C@@H](C(C)(C)C)C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)O)=O)=O

Molecular Formula

C30H43BrN4O4S

Molecular Weight

635.66

References & Citations

[1]Zhu EJ, et al. Design, synthesis and biological evaluation of novel HIF-1α PROTACs degrader as potent anti-cervical cancer agents. Bioorg Med Chem Lett. 2026 Feb 1;131:130443.