NLRP3-IN-85
NLRP3-IN-85 (compound 5d) is a potent NLRP3 inhibitor that targets mitochondria in a ΔΨm-independent manner. NLRP3-IN-85 protects mitochondria from oxidative stress and inflammation damage and suppresses key inflammatory factors (NO, TNF-α, IL-6) . NLRP3-IN-85 relives acute lung injury in mice and inhibits paw edema in rats. NLRP3-IN-85 can be used for acute lung injury (ALI) research[1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR) ; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
OC1=C(O)C=CC(/C=C(C(NCCNC(C2=CC(C=CC(N(CC)CC)=C3)=C3OC2=O)=O)=O)\C(F)(F)F)=C1
Molecular Formula
C26H26F3N3O6
Molecular Weight
533.50
References & Citations
[1]Ran Y, et al. Synthesis of mitochondria-targeted caffeic acid-coumarin fluorescent conjugates to ameliorate inflammation in acute lung injury by protecting mitochondria. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118281.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6; NLRP3
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