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NLRP3-IN-85

NLRP3-IN-85 (compound 5d) is a potent NLRP3 inhibitor that targets mitochondria in a ΔΨm-independent manner. NLRP3-IN-85 protects mitochondria from oxidative stress and inflammation damage and suppresses key inflammatory factors (NO, TNF-α, IL-6) . NLRP3-IN-85 relives acute lung injury in mice and inhibits paw edema in rats. NLRP3-IN-85 can be used for acute lung injury (ALI) research[1].

Product Specifications

UNSPSC

12352005

Target

Interleukin Related; NOD-like Receptor (NLR) ; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

OC1=C(O)C=CC(/C=C(C(NCCNC(C2=CC(C=CC(N(CC)CC)=C3)=C3OC2=O)=O)=O)\C(F)(F)F)=C1

Molecular Formula

C26H26F3N3O6

Molecular Weight

533.50

References & Citations

[1]Ran Y, et al. Synthesis of mitochondria-targeted caffeic acid-coumarin fluorescent conjugates to ameliorate inflammation in acute lung injury by protecting mitochondria. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118281.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IL-6; NLRP3

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