JAK2-IN-17
JAK2-IN-17 (compound 20) is a potent JAK2 allosteric inhibitor. JAK2-IN-17 inhibits full-length JAK2 and JAK2 V617F with IC50s of 160 and 130 nM, respectively. JAK2-IN-17 covalently modifies Lys677 in the pseudokinase domain[1].
Product Specifications
UNSPSC
12352005
Target
JAK
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
NS(C1=CC=C(NC2=NN(C(C3=CC=CC(OS(F)(=O)=O)=C3)=O)C(N)=N2)C=C1)(=O)=O
Molecular Formula
C15H13FN6O6S2
Molecular Weight
456.43
References & Citations
[1]Primi MC, et al. Allosteric inhibition of JAK2 with lysine-reactive compounds that bind the pseudokinase domain. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118274.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2
Curated Selection
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