PROTAC HIF-1α degrader-2

PROTAC HIF-1α degrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. PROTAC HIF-1α degrader-2 promotes HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex. PROTAC HIF-1α degrader-2 inhibits HeLa cell proliferation, migration, and colony formation, and induces apoptosis. PROTAC HIF-1α degrader-2 reduces p-MEK and p-AKT expression in the MAPK and PI3K/AKT pathways. PROTAC HIF-1α degrader-2 can be used for the study of cervical cancer[1].

Product Specifications

CAS Number

[3095636-64-6]

UNSPSC

12352005

Target

Akt; Apoptosis; HIF/HIF Prolyl-Hydroxylase; p38 MAPK; PI3K; PROTACs

Related Pathways

Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; PROTAC

Field of Research

Cancer

Smiles

COC(C1=CC(NC(COC2=CC=C(C=C2)N3CCN(CC3)CCCCCCCC(N[C@@H](C(C)(C)C)C(N4C[C@@H](C[C@H]4C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)O)=O)=O)=O)=C(C=C1)O)=O

Molecular Formula

C50H65N7O9S

Molecular Weight

940.16

References & Citations

[1]Zhu EJ, et al. Design, synthesis and biological evaluation of novel HIF-1α PROTACs degrader as potent anti-cervical cancer agents. Bioorg Med Chem Lett. 2026 Feb 1;131:130443.