PROTAC HDAC6 degrader 7
PROTAC HDAC6 degrader 7 is an orally active, highly efficient, and selective PROTAC degrader targeting histone deacetylase 6 (HDAC6) (IC50 = 118 nM) . PROTAC HDAC6 degrader 7 can eliminate both the catalytic and zinc-finger ubiquitin-binding domain. PROTAC HDAC6 degrader 7 inhibits NLRP3 inflammasome assembly and activation, as well as blocks NF-κB signaling, thereby reducing the transcription and release of key inflammatory factors. PROTAC HDAC6 degrader 7 can reduce the mRNA levels of NLRP3, pro-IL-1β, TNF-α, and IL-6. PROTAC HDAC6 degrader 7 can be used for the study of inflammatory bowel disease (IBD) [1].
Product Specifications
UNSPSC
12352005
Target
HDAC; Interleukin Related; NF-κB; NOD-like Receptor (NLR) ; PROTACs; TNF Receptor
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; NF-κB; PROTAC
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC=C(CN2C3=CC=CC=C3C=CC4=C2C=CC=C4OCCN5CCN(CC5)CC6CCN(C7=CC=C8C(C(N(C8=O)C9CCC(NC9=O)=O)=O)=C7)CC6)C=C1)NNCC
Molecular Formula
C49H54N8O6
Molecular Weight
851.00
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6; IL-6; NF-κB; NLRP3
Frequently Asked Questions
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