PROTAC HDAC6 degrader 7

PROTAC HDAC6 degrader 7 is an orally active, highly efficient, and selective PROTAC degrader targeting histone deacetylase 6 (HDAC6) (IC50 = 118 nM) . PROTAC HDAC6 degrader 7 can eliminate both the catalytic and zinc-finger ubiquitin-binding domain. PROTAC HDAC6 degrader 7 inhibits NLRP3 inflammasome assembly and activation, as well as blocks NF-κB signaling, thereby reducing the transcription and release of key inflammatory factors. PROTAC HDAC6 degrader 7 can reduce the mRNA levels of NLRP3, pro-IL-1β, TNF-α, and IL-6. PROTAC HDAC6 degrader 7 can be used for the study of inflammatory bowel disease (IBD) [1].

Product Specifications

UNSPSC

12352005

Target

HDAC; Interleukin Related; NF-κB; NOD-like Receptor (NLR) ; PROTACs; TNF Receptor

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; NF-κB; PROTAC

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=CC=C(CN2C3=CC=CC=C3C=CC4=C2C=CC=C4OCCN5CCN(CC5)CC6CCN(C7=CC=C8C(C(N(C8=O)C9CCC(NC9=O)=O)=O)=C7)CC6)C=C1)NNCC

Molecular Formula

C49H54N8O6

Molecular Weight

851.00

References & Citations

[1]Sun S, et al. Design, Synthesis, and Anti-inflammatory Activity Evaluation for Hydrazide-Based HDAC6 Targeted Protein Degraders. J Med Chem. 2025 Nov 27;68 (22) :24519-24545.