CypD-IN-6
CypD-IN-6 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 32 nM) and binds to CypD (Kd = 60 nM) . CypD-IN-6 can be used for mitochondrial permeability transition pore (MPTP) related disease research such as ischemia-reperfusion injury and acute pancreatitis1.
Product Specifications
UNSPSC
12352005
Target
Cyclophilin
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
NC1=CC=C(C=C1)CNC(NCC(N2N(CCC2)C3=CC=CC=C3Br)=O)=O
Molecular Formula
C19H22BrN5O2
Molecular Weight
432.31
References & Citations
[1]Awais M, et al. Potent Preorganized Pyrazolidine Cyclophilin D Inhibitors Prevent Mitochondrial and Organ Injury in a Mouse Pancreatitis Disease Model. J Med Chem. 2025;68 (22) :23910-23924. doi:10.1021/acs.jmedchem.5c01146
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cyclophilin D
Curated Selection
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