DHFR-IN-24

DHFR-IN-24, a benzothiazole derivative, is a dihydrofolate reductase (DHFR) inhibitor. DHFR-IN-24 has intrinsic antibacterial activity against both Gram-positive and Gram-negative strains. DHFR-IN-24 synergistically combines DHFR inhibition with photodynamic therapy (PDT) for enhanced antibacterial activity against multidrug-resistant pathogens[1].

Product Specifications

CAS Number

[1088704-78-2]

UNSPSC

12352005

Target

Bacterial; Dihydrofolate reductase (DHFR)

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

CN(C1=CC=C(C=C1)C2=CC=C(S2)/C=C/C3=[N+](C4=CC=CC=C4S3)C)C.[I-]

Molecular Formula

C22H21IN2S2

Molecular Weight

504.45

References & Citations

[1]Yang S, et al. Photo-Augmented DHFR Inhibition: N-Methylbenzothiazole Derivatives against Resistant Gram ± Bacteria. ACS Infect Dis. 2025;11 (12) :3567-3580.