DHFR-IN-24
DHFR-IN-24, a benzothiazole derivative, is a dihydrofolate reductase (DHFR) inhibitor. DHFR-IN-24 has intrinsic antibacterial activity against both Gram-positive and Gram-negative strains. DHFR-IN-24 synergistically combines DHFR inhibition with photodynamic therapy (PDT) for enhanced antibacterial activity against multidrug-resistant pathogens[1].
Product Specifications
CAS Number
1088704-78-2
UNSPSC
12352005
Target
Bacterial; Dihydrofolate reductase (DHFR)
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
CN(C1=CC=C(C=C1)C2=CC=C(S2)/C=C/C3=[N+](C4=CC=CC=C4S3)C)C.[I-]
Molecular Formula
C22H21IN2S2
Molecular Weight
504.45
References & Citations
[1]Yang S, et al. Photo-Augmented DHFR Inhibition: N-Methylbenzothiazole Derivatives against Resistant Gram ± Bacteria. ACS Infect Dis. 2025;11 (12) :3567-3580.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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