KRAS G12D-IN-34

KRAS G12D-IN-34 (Compound 13) is a KRAS (G12D) inhibitor with IC50 values for KRAS (G12D) and KRAS (WT) of 1.05 nM and 1.59 μM respectively. KRAS G12D-IN-34 can be used for research on non-small cell lung cancer[1].

Product Specifications

CAS Number

[3102130-17-3]

UNSPSC

12352005

Target

Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CC1=C(C(N)=CC(C2=NC3=C(C(NCC4=CN=CC=C4)=C2F)C(N5[C@H]([C@@H](O3)C)[C@H](CC6)N[C@H]6C5)=O)=C1C(F)(F)F)F

Molecular Formula

C28H27F5N6O2

Molecular Weight

574.54

References & Citations

[1]Renner AC, Kargbo RB. Dual-State KRAS G12C Inhibitors as Emerging Therapeutics for Brain and Lung Metastases. ACS Medicinal Chemistry Letters. 2025 Nov 10.