KRAS G12D-IN-34
KRAS G12D-IN-34 (Compound 13) is a KRAS (G12D) inhibitor with IC50 values for KRAS (G12D) and KRAS (WT) of 1.05 nM and 1.59 μM respectively. KRAS G12D-IN-34 can be used for research on non-small cell lung cancer[1].
Product Specifications
CAS Number
[3102130-17-3]
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC1=C(C(N)=CC(C2=NC3=C(C(NCC4=CN=CC=C4)=C2F)C(N5[C@H]([C@@H](O3)C)[C@H](CC6)N[C@H]6C5)=O)=C1C(F)(F)F)F
Molecular Formula
C28H27F5N6O2
Molecular Weight
574.54
References & Citations
[1]Renner AC, Kargbo RB. Dual-State KRAS G12C Inhibitors as Emerging Therapeutics for Brain and Lung Metastases. ACS Medicinal Chemistry Letters. 2025 Nov 10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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