LT-104A
LT-104A is a potent PDE4 inhibitor that elevates intracellular cAMP levels (EC50 = 1.9 μM) and inhibits PDE4D3 activity (IC50 = 9.3 μM) . LT-104A activates the cAMP-PKA-CREB anti-inflammatory signaling pathway and suppresses NF-κB-related gene expression (Il1b and Nos2) . LT-104A can be used for inflammation-related disease research[1].
Product Specifications
CAS Number
2574572-03-3
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC=CC2=C1C=CC=C2)OC[C@@H]3[C@@H](C4=CC=C(OC)C(OC)=C4)OC[C@@H]3CC5=CC=C(OC)C(OC)=C5
Molecular Formula
C33H34O7
Molecular Weight
542.62
References & Citations
[1]Coffey C, et al. Identification of a novel PDE4 inhibitor inspired by leoligin-derived lignans. Eur J Med Chem. 2026;302 (Pt 1) :118285. doi:10.1016/j.ejmech.2025.118285
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4
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