PARP1-IN-49
PARP1-IN-49 is a selective PARP1 inhibitor with an IC50 of 23.56 nM and a Kd of 17.78 nM. PARP1-IN-49 shows a selectivity for PARP1 over PARP2. PARP1-IN-49 leads to the induction of DNA damage, cell cycle arrest, and apoptosis. PARP1-IN-49 also increases intracellular ROS levels and inhibits cell migration. PARP1-IN-49 can be used for the research of breast cancer and ovarian cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; PARP; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NC)C1=CC(C2=CC=C(OC(N3)=O)C3=C2)=CC(F)=C1
Molecular Formula
C15H11FN2O3
Molecular Weight
286.26
References & Citations
[1]Zheng Y, et al. Coixol derivatives induce DNA damage by targeting PARP1. Eur J Med Chem. 2026;302 (Pt 2) :118307.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP2
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