β-carboline-ACS81

β-carboline-ACS81 is a β-carboline derivative with potent antitumor properties. β-carboline-ACS81 induces apoptosis through the collapse of mitochondrial membrane potential and arrests cell cycle at G2/M phase in HL-60 cells. β-carboline-ACS81 possesses potent antiproliferative activity against HL-60 cells (IC50 = 1.52 μM) . β-carboline-ACS81 can be used for the research of leukemia, histiocytic lymphoma, hepatocellular carcinoma, malignant melanoma, colorectal carcinoma and lung carcinoma[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Mitochondrial Metabolism

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

CN(C)C1=CC=C(C2=NC(COC(CCSSCC=C)=O)=CC3=C2NC4=C3C=CC=C4)C=C1

Molecular Formula

C26H27N3O2S2

Molecular Weight

477.64

References & Citations

[1]Hu X, et al. Enhancement of anticancer potential of novel β-carboline derivatives by ACS81 hybridization. Bioorg Med Chem Lett. 2026 Feb 1;131:130440.