β-carboline-ACS81
β-carboline-ACS81 is a β-carboline derivative with potent antitumor properties. β-carboline-ACS81 induces apoptosis through the collapse of mitochondrial membrane potential and arrests cell cycle at G2/M phase in HL-60 cells. β-carboline-ACS81 possesses potent antiproliferative activity against HL-60 cells (IC50 = 1.52 μM) . β-carboline-ACS81 can be used for the research of leukemia, histiocytic lymphoma, hepatocellular carcinoma, malignant melanoma, colorectal carcinoma and lung carcinoma[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Mitochondrial Metabolism
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CN(C)C1=CC=C(C2=NC(COC(CCSSCC=C)=O)=CC3=C2NC4=C3C=CC=C4)C=C1
Molecular Formula
C26H27N3O2S2
Molecular Weight
477.64
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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