TEAD-IN-23

TEAD-IN-23 (Compound 22) is an efficient pan-TEAD inhibitor with an IC50 of 10 nM. TEAD-IN-23 exhibits potent anti-proliferative activity in both NCI-H226 and MSTO-211H. TEAD-IN-23 causes complete tumor regression in the MSTO-211H xenograft tumor model. TEAD-IN-23 can be used for the study of mesothelioma and hepatocellular carcinoma[1].

Product Specifications

CAS Number

[3074990-47-6]

UNSPSC

12352005

Target

YAP

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC1=CC(C2=CN(C3=C2C(Cl)=NC=C3)CCO)=CC(OC4=CC=C(C=C4)C(F)(F)F)=C1

Molecular Formula

C23H18ClF3N2O2

Molecular Weight

446.85

References & Citations

[1]Heinrich T, et al. Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors. J Med Chem. 2025 Nov 27;68 (22) :24603-24623.