TEAD-IN-23
TEAD-IN-23 (Compound 22) is an efficient pan-TEAD inhibitor with an IC50 of 10 nM. TEAD-IN-23 exhibits potent anti-proliferative activity in both NCI-H226 and MSTO-211H. TEAD-IN-23 causes complete tumor regression in the MSTO-211H xenograft tumor model. TEAD-IN-23 can be used for the study of mesothelioma and hepatocellular carcinoma[1].
Product Specifications
CAS Number
3074990-47-6
UNSPSC
12352005
Target
YAP
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=CC(C2=CN(C3=C2C(Cl)=NC=C3)CCO)=CC(OC4=CC=C(C=C4)C(F)(F)F)=C1
Molecular Formula
C23H18ClF3N2O2
Molecular Weight
446.85
References & Citations
[1]Heinrich T, et al. Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors. J Med Chem. 2025 Nov 27;68 (22) :24603-24623.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TEAD
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