HBV-IN-54
HBV-IN-54 is a selective and orally active HBV inhibitor. HBV-IN-54 exhibits anti-HBV activity in both HepAD38 cells (EC50 = 0.020 μM, CC50 > 100 μM) and HLCZ01 cells (EC50 = 0.024 μM, CC50 > 100 μM) . HBV-IN-54 inhibits viral replication in vivo. HBV-IN-54 displays favorable physicochemical properties and high plasma stability. HBV-IN-54 can be used for research on Hepatitis B (HBV) [1].
Product Specifications
UNSPSC
12352005
Target
HBV
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=C(C=C(C(F)=C1)NC(N2CCN(CC2)CCO)=S)C(NC3=CC(C)=C(C=C3)F)=O
Molecular Formula
C22H26F2N4O2S
Molecular Weight
448.53
References & Citations
[1]Liang M, et al. Multisite Occupancy and Multidimensional Optimization: Design and Evaluation of Piperazine-Thioureidobenzamide Derivatives as Potent HBV Capsid Assembly Modulators. J Med Chem. 2025 Nov 27;68 (22) :24358-24380.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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