PROTAC Sirt2 Degrader-2
PROTAC Sirt2 Degrader-2 is a highly efficient and selective PROTAC degrader targeting SIRT2. PROTAC Sirt2 Degrader-2 demonstrates the most potent anti-proliferative activity both in vitro and in vivo. PROTAC Sirt2 Degrader-2 leads to a marked increase in H4K16Ac levels. PROTAC Sirt2 Degrader-2 significantly suppresses clonogenic formation and migration, induces cell cycle arrest, and promotes apoptosis. PROTAC Sirt2 Degrader-2 inhibits the AKT/mTOR signaling pathway by indirectly degrading SIRT2 and blocking downstream protein phosphorylation, thereby disrupting the signaling cascade and suppressing tumor development. PROTAC Sirt2 Degrader-2 can be used for the study of ovarian cancer[1].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; mTOR; PROTACs; Sirtuin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR; PROTAC
Field of Research
Cancer
Smiles
CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(NC(CCCCCNC3=C(CN(C4C(NC(CC4)=O)=O)C5=O)C5=CC=C3)=O)C=C2)=S)=O)C=C1
Molecular Formula
C37H42N6O5S
Molecular Weight
682.83
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt; mTOR; SIRT2
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