CXCR2-IN-3
CXCR2-IN-3 is a CXCR2 inhibitor with an IC50 of 11.37 μM. CXCR2-IN-3 mediates CXCR2-Ca2+ signalling inhibition halted autophagic flux, subsequently facilitating ROS-mediated apoptotic cell death. CXCR2-IN-3 suppresses the CXCR2-NLRP3 canonical pathway, suppressing pre-tumorigenic markers. CXCR2-IN-3 causes autophagy-dependent cell death in polyploid giant cancer cells (PGCCs) . CXCR2-IN-3 can be used for the research of oral squamous cell carcinoma (OSCC) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Autophagy; CXCR; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
O=C1C(C(NC2=CC3=C(NC=C3)C=C2)=C1NC4=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C4)=O
Molecular Formula
C21H13F6N3O3
Molecular Weight
469.34
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR2; NLRP3
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