PARP1/EZH2-IN-1
PARP1/EZH2-IN-1 is a selective PARP1 and EZH2 dual inhibitor. PARP1/EZH2-IN-1 has IC50s of 28 nM, 414 nM and 74 nM for PARP1, PARP2 and EZH2, respectively. PARP1/EZH2-IN-1 inhibits the proliferation and migration of TNBC cells (triple-negative breast Cancer cells) . PARP1/EZH2-IN-1 induces PANoptosis (Apoptosis, Pyroptosis and Necroptosis), increases the level of reactive oxygen species (ROS), and activates related inflammatory pathways. PARP1/EZH2-IN-1 can be used in triple-negative breast cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Histone Methyltransferase; Necroptosis; PARP; Pyroptosis; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CCC1=CC(N=CC(CN2CCN(C3=NC=C(C4=CC(N(C(CCl)=O)CC)=CC(C(NCC5=C(C)C=C(C)NC5=O)=O)=C4)C=C3)CC2)=C6)=C6NC1=O
Molecular Formula
C39H43ClN8O4
Molecular Weight
723.26
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2; PARP1; PARP2
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Murashige & Skoog Modified Medium w/ CaCl₂ & Gamborg B5 vitamins; w/o Sucrose & Agar
