Tubulin-IN-62

Tubulin-IN-62 is a tubulin inhibitor targeting the colchicine-binding site. Tubulin-IN-62 exhibits IC50 values of 17.2 nM and 19.3 nM against SKOV3 and HCC827 cells, respectively. Tubulin-IN-62 inhibits microtubule polymerization, arrests the cell cycle at the G2/M phase, and induces apoptosis. Tubulin-IN-62 demonstrates significant antitumor efficacy in vivo with good tolerability. Tubulin-IN-62 can be used in ovarian cancer and non-small cell lung cancer (NSCLC) research[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; Phosphatase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC1=CC(C(N2)=C[C@@H](C3=CC(OC)=C(OC)C(OC)=C3)N4C2=NN=N4)=CC(C)=C1

Molecular Formula

C21H23N5O3

Molecular Weight

393.44

References & Citations

[1]Guo Y, et al. Structure-guided design of potent tetrazolo[1,5-a]pyrimidine-based tubulin inhibitors with in vivo antitumor activity. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118288.1.