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PROTAC FSP1 degrader 1

PROTAC FSP1 degrader 1 is a highly efficient and selective PROTAC degrader targeting FSP1. PROTAC FSP1 degrader 1 significantly induces the accumulation of intracellular lipid peroxides. PROTAC FSP1 degrader 1 exhibits synergistic induction of ferroptosis with GPX4 inhibitors. PROTAC FSP1 degrader 1 upregulates the mRNA expression of ferroptosis-related proteins (GPX4, FTH1, ACSL4, TfR1, FSP1) . PROTAC FSP1 degrader 1 can be used for the study of triple-negative breast cancer[1].

Product Specifications

CAS Number

3096510-51-6

UNSPSC

12352005

Target

Ferroptosis; Glutathione Peroxidase; Transferrin Receptor

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C(NC1=C(C#N)C(C2=CC=C(C)C=C2)=C(C#N)C3=NC4=CC=CC=C4N13)CC(NCCCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O

Molecular Formula

C41H35N9O6

Molecular Weight

749.77

References & Citations

[1]Huang Y, et al. Design, synthesis, and induction of tumor ferroptosis activity of a novel FSP1 protein degrading agent. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118270.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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