FGFR4-IN-24
FGFR4-IN-24 is a selective irreversible covalent FGFR4 inhibitor (IC50 = 1.2 nM) . FGFR4-IN-24 shows much weaker activity against the other three FGFR family kinases (FGFR1-3) . FGFR4-IN-24 inhibits the FGF19/FGFR4 signaling pathway, effectively suppressing the proliferation of the HuH-7 HCC cell line (GI50 = 17 nM) . FGFR4-IN-24 exhibits significant antitumor activity in a HuH-7 mouse xenograft model. FGFR4-IN-24 can be used for the research of hepatocellular carcinoma[1].
Product Specifications
CAS Number
3053546-73-6
UNSPSC
12352005
Target
FGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C=CC(NC1=CC=CC=C1NC2=CC=C(C(C(C3=C(F)C=CC(C(NC4CC4)=O)=C3)=O)=CN5)C5=N2)=O
Molecular Formula
C27H22FN5O3
Molecular Weight
483.49
References & Citations
[1]Huang J, et al. Development of a series of novel potent and selective irreversible covalent FGFR4 inhibitors with a mix-and-match strategy. Eur J Med Chem. 2026 Jan 15;302 (Pt 2) :118303.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FGFR4
Frequently Asked Questions
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