FGFR4-IN-24

FGFR4-IN-24 is a selective irreversible covalent FGFR4 inhibitor (IC50 = 1.2 nM) . FGFR4-IN-24 shows much weaker activity against the other three FGFR family kinases (FGFR1-3) . FGFR4-IN-24 inhibits the FGF19/FGFR4 signaling pathway, effectively suppressing the proliferation of the HuH-7 HCC cell line (GI50 = 17 nM) . FGFR4-IN-24 exhibits significant antitumor activity in a HuH-7 mouse xenograft model. FGFR4-IN-24 can be used for the research of hepatocellular carcinoma[1].

Product Specifications

CAS Number

[3053546-73-6]

UNSPSC

12352005

Target

FGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

C=CC(NC1=CC=CC=C1NC2=CC=C(C(C(C3=C(F)C=CC(C(NC4CC4)=O)=C3)=O)=CN5)C5=N2)=O

Molecular Formula

C27H22FN5O3

Molecular Weight

483.49

References & Citations

[1]Huang J, et al. Development of a series of novel potent and selective irreversible covalent FGFR4 inhibitors with a mix-and-match strategy. Eur J Med Chem. 2026 Jan 15;302 (Pt 2) :118303.