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EP4 receptor agonist 3 prodrug

EP4 receptor agonist 3 prodrug (Compound 9) is a prodrug of EP4 receptor agonist (Compound 1a) . EP4 receptor agonist 3 prodrug itself has no agonistic activity on the EP4 receptor and needs to be specifically hydrolyzed by intestinal alkaline phosphatase (IAP) in the intestine to release the active molecule, which then exerts the EP4 receptor agonistic effect locally in the intestine. EP4 receptor agonist 3 prodrug has colonic targeting properties and significantly alleviates colitis in mice[1].

Product Specifications

UNSPSC

12352005

Target

Drug Derivative

Related Pathways

Others

Field of Research

Inflammation/Immunology

Smiles

FC([C@H](OCCP(O)(O)=O)/C=C/[C@@H]1N(CCCCCCC(O)=O)C(CC1)=O)(F)C2=CC=CC=C2

Molecular Formula

C23H32F2NO7P

Molecular Weight

503.47

References & Citations

[1]Kantham S, et al. Development of novel GI-centric prostaglandin E2 receptor type 4 (EP4) agonist prodrugs as treatment for ulcerative colitis and other intestinal inflammatory diseases. Bioorg Med Chem Lett. 2025 Apr 15;119:130093.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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