UB-MBX-46
UB-MBX-46 is a potent and selective P2X7 receptor antagonist with IC50s of 0.514 nM (hP2X7R), 40.6 nM (rP2X7R), and 4.52 nM (mP2X7R), respectively. UB-MBX-46 interacts with the classical allosteric pocket of the human P2X7 receptor. UB-MBX-46 can be used for cancer, atherosclerosis, and neurode generation research[1].
Product Specifications
UNSPSC
12352005
Target
P2X Receptor
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Smiles
O=C(NNC1=C(C=CC=C1)Cl)C23C(CC4(C)C5(C)C3)CC4(C)C5(C)C2
Molecular Formula
C21H27ClN2O
Molecular Weight
358.90
References & Citations
[1]Oken AC, et al. A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor. Nat Commun. 2025 Sep 15;16 (1) :8283.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X7 Receptor
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TRC-C365815-25G 25 g
(3R,5S)-6-Chloro-3,5-dihydroxyhexanoic Acid tert-Butyl Ester (~90%)
Sign In for Pricing
View Details 
MCB07F-CON A 10x 96 Well Plates
Concanavalin A Coated - 96 well Solid plates - Black PS
Sign In for Pricing
View Details 
BNC402025-500 1x 500 µL
MMP9 (MMP9/2025R), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 