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UB-MBX-46

UB-MBX-46 is a potent and selective P2X7 receptor antagonist with IC50s of 0.514 nM (hP2X7R), 40.6 nM (rP2X7R), and 4.52 nM (mP2X7R), respectively. UB-MBX-46 interacts with the classical allosteric pocket of the human P2X7 receptor. UB-MBX-46 can be used for cancer, atherosclerosis, and neurode generation research[1].

Product Specifications

UNSPSC

12352005

Target

P2X Receptor

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Smiles

O=C(NNC1=C(C=CC=C1)Cl)C23C(CC4(C)C5(C)C3)CC4(C)C5(C)C2

Molecular Formula

C21H27ClN2O

Molecular Weight

358.90

References & Citations

[1]Oken AC, et al. A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor. Nat Commun. 2025 Sep 15;16 (1) :8283.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

P2X7 Receptor

Frequently Asked Questions

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