UB-MBX-46
UB-MBX-46 is a potent and selective P2X7 receptor antagonist with IC50s of 0.514 nM (hP2X7R), 40.6 nM (rP2X7R), and 4.52 nM (mP2X7R), respectively. UB-MBX-46 interacts with the classical allosteric pocket of the human P2X7 receptor. UB-MBX-46 can be used for cancer, atherosclerosis, and neurode generation research[1].
Product Specifications
UNSPSC
12352005
Target
P2X Receptor
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Smiles
O=C(NNC1=C(C=CC=C1)Cl)C23C(CC4(C)C5(C)C3)CC4(C)C5(C)C2
Molecular Formula
C21H27ClN2O
Molecular Weight
358.90
References & Citations
[1]Oken AC, et al. A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor. Nat Commun. 2025 Sep 15;16 (1) :8283.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X7 Receptor
Curated Selection
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