LIQ1
LIQ1, a flavonoid derivative, is a potent Pyruvate kinase M2 (PKM2) allosteric inhibitor (IC50 = 0.39 μM; Kd = 4.5 μM) targeting Arg43 within the polyarginine pocket. LIQ1 exhibits efficacy in a mouse model of LPS -induced endotoxemia, preventing the nuclear translocation of PKM2 and inhibiting its binding to HIF-1α, thereby suppressing IL-1β transcription. LIQ1 can be used for the research of endotoxemia[1].
Product Specifications
CAS Number
2606032-80-6
UNSPSC
12352005
Target
Interleukin Related; Pyruvate Kinase
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC=CC=C1C2CC(C3=CC=C(C=C3O2)O)=O)O
Molecular Formula
C16H12O5
Molecular Weight
284.26
References & Citations
[1]Wang X, et al. Discovery of liquiritigenin derivatives as PKM2 allosteric inhibitors via targeting the polyarginine pocket. Bioorg Chem. 2025;167:109212.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKM2
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