BChE-IN-46

BChE-IN-46 is a selective and brain-penetrant BChE inhibitor (eqBChE IC50 = 7.44 x 10−5 μM, SI > 270,000; hBChE, IC50 = 1.48 x 10−3 μM) . BChE-IN-46 has COX-2 inhibitory activity (IC50 = 0.11 μM) . BChE-IN-46 exhibits neuroprotective effects, enhances acetylcholine levels, and alleviates cognitive deficits, anxiety, and learning/memory impairments. BChE-IN-46 can be used for the development of anti-Alzheimer's disease drugs[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE) ; COX

Related Pathways

Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CC(C=C1)=CC(OC(N2CCC2)=O)=C1C(NCCC3=CNC4=CC(N(C)C)=CC=C43)=O

Molecular Formula

C24H28N4O3

Molecular Weight

420.50

References & Citations

[1]Wu K. et al. Design of N-salicyltryptamines-based highly selective BChE inhibitors to elevate brain acetylcholine, improve learning, and reduce amyloid-β in Alzheimer's disease. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118273.