EG01449
EG01449 is a quinoline-based antagonist of Neuropilin-1 (NRP1) with an Kd of 0.6 µM. EG01449 competitively inhibits the binding of VEGFA to NRP1 with an IC50 of 362 nM. EG01449 prevents VEGFA-induced pain by inhibiting NRP1-dependent signaling and reducing sodium currents in sensory neurons. EG01449 can be used for the research of nociceptive pain[1].
Product Specifications
UNSPSC
12352005
Target
VEGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C([C@H](CCCNC(N)=N)NC(C1=C(C=CS1)NS(=O)(C2=C3N=CC=CC3=CC(NCC4=CSC(N5CCNCC5)=N4)=C2)=O)=O)O.O=CO
Molecular Formula
C29H36N10O7S3
Molecular Weight
732.85
References & Citations
[1]Hestehave S, et al. Quinoline-Based Neuropilin‑1 Antagonists Exhibit a Pure Antagonist Profile and Block Vascular Endothelial Growth Factor-Induced Pain. ACS Pharmacol Transl Sci. 2025;8 (11) :3844-3871. Published 2025 Oct 29.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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