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LSD1-IN-46

LSD1-IN-46 is a potent and orally active Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 0.082 μM. LSD1-IN-46 interrupts the β-catenin-mediated transcriptional program, thereby suppressing the stemness of gastric cancer cells. LSD1-IN-46 exhibits strong anti-tumor activity. LSD1-IN-46 can be used for the research of gastric cancer[1].

Product Specifications

CAS Number

2982716-97-0

UNSPSC

12352005

Target

Histone Demethylase

Related Pathways

Epigenetics

Field of Research

Cancer

Smiles

CN(C)C(CC1)CCN1CCCN2C3=C(C=CC=C3)OC4=CC=CC=C24

Molecular Formula

C22H29N3O

Molecular Weight

351.49

References & Citations

[1]Dai XJ, et al. Identification of Novel Phenoxazine-Derived LSD1 Inhibitors Suppressing Gastric Cancer Stemness by β-Catenin Transcriptional Regulation. J Med Chem. 2025;68 (21) :22896-22917.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

KDM1/LSD1

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