PDE2-IN-1
PDE2-IN-1 is a potent and orally active PDE2 inhibitor with an IC50 of 0.6 μM, demonstrating neuroprotective effects. PDE2-IN-1 modulates the PKA/CREB/BDNF signaling pathway by inhibiting PDE2. PDE2-IN-1 improves memory deficits and cognitive impairment in an okadai acid (OKA) -induced Alzheimer’s disease (AD) mouse model. PDE2-IN-1 can be used for the research of AD[1].
Product Specifications
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; PKA
Related Pathways
Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C1C2=NN(CCO)C(C(NC(C3=CC=C(C(F)(F)F)C=C3)C)=O)=C2CCN1
Molecular Formula
C18H19F3N4O3
Molecular Weight
396.36
References & Citations
[1]Yang F, et al. Discovery of novel 2,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridine-7-one derivatives as PDE2 inhibitors with Alzheimer's disease therapeutic potential. Eur J Med Chem. 2026;302 (Pt 1) :118302.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE2
Curated Selection
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