TLR7/8 agonist 14
TLR7/8 agonist 14 is a TLR7 and TLR8 agonist with EC50 values of 0.53 μM and 4.3 μM, respectively. TLR7/8 agonist 14 increases the secretion of the proinflammatory cytokines TNF-α, IL-1β, IL-8 and IFN-γ. TLR7/8 agonist 14 increases cytokine secretion and expression of CD86. LR7/8 agonist 14 can be used for research colorectal carcinoma[1].
Product Specifications
UNSPSC
12352005
Target
IFNAR; Interleukin Related; TNF Receptor; Toll-like Receptor (TLR)
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1N(C(CCCCCC)CO)C=NC2=C1C(C)=CC=C2Cl
Molecular Formula
C17H23ClN2O2
Molecular Weight
322.83
References & Citations
[1]Strašek Benedik N, et al. Synthesis and structure-activity relationship study of novel quinazolin-4 (3H) -one derivatives as Toll-like receptor 7 and 8 agonists with immunomodulatory activity. Eur J Med Chem. 2026 Jan 15;302 (Pt 2) :118360.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-8; TLR7; TLR8; TNFRSF5/CD40
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